Research Interests

•Protein Structure and Function

•Plant, Human and Bacterial Beta-glucosidases Structure, Function and Application

•Chemi-enzymatic synthesis of glycoconjugates as possible drugs and bioactive compounds.

•Biomedical applications of plant proteins and synchrotron methods of characterization.

•Immune cell surface proteins

•Biosensors

•Cancer cell genetics and markers

•Bacterial cell wall synthesis enzymes as drug targets

•Acting binding proteins and their calcium binding

•Application of natural products and agricultural waste to cosmetic production.

Recent Publications

Papers in 2022

Chueakwon P, Jatooratthawichot P, Talabnin K, Ketudat Cairns JR, Talabnin C. 2022. Inhibition of ceramide glycosylation enhances cisplatin sensitivity in cholangiocarcinoma by limiting the activation of the ERK signaling pathway. Life 12(3): 351. https://doi.org/10.3390/life12030351

Shim SH, Mahong B, Lee SY, Kongdin M, Lee C, Kim YJ, Qu G, Zhang D, Ketudat Cairns JR, Jeon JS. 2022. Rice β-glucosidase Os12BGlu38 is required for synthesis of intine cell wall and pollen fertility. Journal of Experimental Botany 73(3): 784–800. https://doi.org/10.1093/jxb/erab439

Gorantla JN, Santhi M, Hua Y, Ketudat Cairns JR. 2022. Total synthesis of ceramides and β-O-glucosylceramides via intramolecular fatty acyl group migration. New Journal of Chemistry 46: 3270- 3276. doi: 10.1039/d1nj05372h

Huang M, Pengthaisong S, Charoenwattanasatien R, Thinkumrob N, Jitonnom J, Ketudat Cairns JR. 2022. Systematic functional and computational analysis of glucose-binding residues in glycoside hydrolase family GH116. Catalysts 12(3): 343. https://doi.org/10.3390/catal12030343

Horikoshi S, Saburi W, Yu J, Matsuura H, Ketudat Cairns JR, Yao M, Mori H. 2022. Substrate specificity of glycoside hydrolase family 1 β-glucosidase AtBGlu42 from Arabidopsis thaliana and its molecular mechanism. Bioscience, Biotechnology, and Biochemistry 86(2): 231–245, https:/doi.org/10.1093/bbb/zbab200

Kantaputra P, Guven Y, Kalayci T, Özer PK, Panyarak W, Intachai W, Olsen B, Carlson BM, Praditsap O, Tongsima S, Ngamphiw C, Jatooratthawichot P, Tucker AS, Ketudat Cairns JR. (2022) Expanding genotypic and phenotypic spectrums of LTBP3 variants in Dental Anomalies and Short Stature syndrome. Clinical Genetics https://doi.org/10.1111/cge.14134

Kantaputra P, Jatooratthawichot P, Tantachamroon O, Nanekrungsan K, Intachai W, Olsen B, Tongsima S, Ngamphiw C, Ketudat Cairns JR. (2022) Novel dental anomaly−associated mutations in WNT10A protein binding sites. International Dental Journal https://doi.org/10.1016/j.identj.2022.04.006

Papers in 2021

Lowhalidanon, K., Khunkaewla, P. Discrimination between minimally modified LDL and fully oxidized LDL using monoclonal antibodies. Analytical Biochemistry 619,114103

Talabnin, K., Talabnin, C., Khiaowichit, J., (...), Azadi, P., Sripa, B. High expression of tissue O-linked glycans is associated with a malignant phenotype of cholangiocarcinoma. Journal of International Medical Research 49(2)

Dunkhunthod, B., Talabnin, C., Murphy, M., (...), Sittisart, P., Eumkeb, G. Gymnema inodorum (Lour.) Decne. Extract Alleviates Oxidative Stress and Inflammatory Mediators Produced by RAW264.7 Macrophages. Oxidative Medicine and Cellular Longevity 2021,8658314

Oranich Thongsri, Sawitri Srisuwan, Paritat Thaitalay, Rawee Dangwiriyakul, Prasert Aengchuan, Narong Chanlek, Chutima Talabnin, Sanong Suksaweang & Sirirat Tubsungnoen Rattanachan Influence of Al2O3 and P2O5 contents in sol-gel ionomer glass system on the structure and their cement properties. Journal of Sol-Gel Science and Technology 98(3), pp. 441-451

Paritat Thaitalay,Oranich Thongsri,Rawee Dangviriyakul,Sawitri Srisuwan,Chutima Talabnin,Sanong Suksaweang,Nuan La-ong Srakaew,Sirirat Tubsungnoen Rattanachan Influence of polyacrylic acid (PAA)/Na2HPO4 mixture on biphasic calcium phosphate cement: Enhancing strength and cell viability. International Journal of Applied Ceramic Technology 18(4), pp. 1365-1378.

Kongdin M, Mahong B, Lee S-K, Shim S-H, Jeon J-S, Ketudat Cairns JR. (2021) Action of multiple rice β-glucosidases on abscisic acid glucose ester. International Journal of Molecular Sciences. 22(14): 7593.

Pengthaisong S, Hua Y, Ketudat Cairns JR. (2021) Structural basis for transglycosylation in glycoside hydrolase family GH116 glycosynthases. Archives of Biochemistry and Biophysics 706: 108924.

Gorantla J, Santhi M, Pengthaisong S, Ngiwsara L, Sawangareetrakul P, Chokchaisiri S, Kittakoop P, Svasti J, Ketudat Cairns J. (Accepted 9/9/2021) Chemoenzymatic and protecting-group-free synthesis of 1,4-substituted 1,2,3-triazole-α-D-glucosides with potent inhibitory activity towards lysosomal α-glucosidase. ACS Omega 6(39): 25710–25719.

Baiya S, Pengthaisong S, Kitjaruwankul S, Ketudat Cairns JR 2021. Structural analysis of rice Os4BGlu18 monolignol β-glucosidase. PLoS ONE 16(1): e0241325.

Ngivprom U, Kluaiphanngam S, Ji W, Siriwibool S, Kamkaew A, Ketudat Cairns JR, Zhang Q, Lai RY. 2021. Characterization of NucPNP and NucV Involved in the Early Steps of Nucleocidin Biosynthesis in Streptomyces calvus. RSC Advances 11: 3510-3515.

Treekoon J, Pewklang T, Chansaenpak K, Gorantla JN, Pengthaisong S, Lai R-Y, Ketudat Cairns JR, Kamkaew A. (2021) Glucose conjugated Aza-BODIPY for enhanced photodynamic cancer therapy. Organic & Biomolecular Chemistry 19: 5867–5875.

Shim SH, Mahong B, Lee SY, Kongdin M, Lee C, Kim YJ, Qu G, Zhang D, Ketudat Cairns JR, Jeon JS. Rice β-glucosidase Os12BGlu38 is required for synthesis of intine cell wall and pollen fertility. Journal of Experimental Botany erab439

Ngiwsara L, Vatanavicharn N, Sawangareetrakul P, Liammongkolkul S, Ratanarak P, Boonyawat B, Srisomsap C, Champattanachai V, Ketudat-Cairns J, Wasant P, Svasti J. 2021. Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants. Molecular Biology Reports 48: 2063–2070.

Sawangareetrakul P, Ngiwsara L, Champattanachai V, Chokchaichamnankit D, Saharat K, Ketudat Cairns JR, Srisomsap C, Khwanraj K, Dharmasaroja P, Pulkes T, Svasti J. 2021. Aberrant proteins expressed in skin fibroblasts of Parkinson’s disease patients carrying heterozygous variants of glucocerebrosidase and parkin genes. Biomedical Reports 14(4): 36

Sari DRT, Paemanee A, Roytrakul S, Ketudat Cairns JR, Safitri A, Fatchiyah F. 2021. The black rice cultivar from Java Island at Indonesia revealed the genomic, proteomic, and anthocyanin of nutritional value performance. Acta Biochimica Polonica 68(1): 55-63.

Kantaputra PN, Dejkhamron P, Intachai W, Ngamphiw C, Ketudat Cairns JR, Kawasaki K, Ohazama A, Olsen B, Tongsima S, Angkurawaranon S. (Accepted 25 January, 2021) A novel P3H1 mutation is associated with Osteogenesis imperfecta type VIII and dental anomalies. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Meelua W, Wanjai T, Thinkumrob N, Olah J, Mujika JI, Ketudat-Cairns JR, Hannongbua S, Jitonnom J. (2021) Active site dynamics and catalytic mechanism in arabinan hydrolysis catalyzed by GH43 endo-arabinanase from QM/MM molecular dynamics simulation and potential energy surface. Journal of Biomolecular Structure & Dynamics https://doi.org/10.1080/07391102.2021.1898469

Kantaputra P, Chaowattanapanit S, Kiratikanon S, Chaiwarith R, Choonhakarn C, Intachai W, Quarto N, Tongsima S, Ketudat Cairns JR, Ngamphiw C, McGrath JA, Chuamanochan M. (2021) SERPINA1, generalized pustular psoriasis, and adult-onset immunodeficiency Journal of Dermatology 48(10): 1597-1601.

Some 2019 papers from SUT Biochemistry and Biochemical Technology (SUT School of Chemistry):

Streltzov, Luang et al. (2019) Discovery of processive catalysis by an exo-hydrolase with a pocket-shaped active site. Nature Communications 10, Article number: 2222.

Tran, Blay et al. (2019) Engineering faster transglycosidases and their acceptor specificity. Green Chemistry 2019,21, 2823-2836.

Gorantla et al. (2019) Gram scale production of 1-azido-β-D-glucose via enzyme catalysis for the synthesis of 1,2,3-triazole-glucosides. RSC Advances, 9, 6211-6220

Teanphonkrang et al. (2019) Amperometric Detection of the Urinary Disease Biomarkerp-HPA by Allosteric Modulation of a Redox Polymer-Embedded BacterialReductase. ACS Sensors 4: 1270-1278

Kantaputra et al. (2019) ADAMTSL1 and mandibular prognathism. Clinical Genetics 95(4):507-515

Kantaputra et al. (2019) Oral manifestations in patients and dogs with mucopolysaccharidosis Type VII. American Journal of Medical Genetics A 179(3): 486-493.